File this one under odd randomized trials:
This Candian Trial randomized 216 patients undergoing RT for head and neck cancer were randomized to recieve RT in the morning (8-10AM) vs RT in the afternoon (4-6PM). Why, you ask? This is based on observations that oral mucosal cells exhibit a circadian rhythm tend to be in G1 in the morning and in M by the afternoon. Thus RT should be less toxic to the mucosa in the AM.
They didn't quite find statistical significance on their main endpoint, they did find some subgroup signals.