Thursday, December 18, 2008

RT in the AM better than in the PM?

File this one under odd randomized trials:

This Candian Trial randomized 216 patients undergoing RT for head and neck cancer were randomized to recieve RT in the morning (8-10AM) vs RT in the afternoon (4-6PM).  Why, you ask?  This is based on observations that oral mucosal cells exhibit a circadian rhythm tend to be in G1 in the morning and in M by the afternoon.  Thus RT should be less toxic to the mucosa in the AM.  

They didn't quite find statistical significance on their main endpoint, they did find some subgroup signals.

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