EORTC & German trial of Postop RT for Prostate Cancer

In response to a question - here are the two other trials of post op RT for Prostate Cancer referred to in the last post

ARO 96-02 (German):
Wiegel ASCO 2005 (abstract only)

•385 s/p RP, pT3N0, undetectable PSA

–60 Gy post op RT to prostate bed

–NFT

•If PSA detectable, 66Gy postop RT (20%of patients entered)

•32 in RT arm did not receive RT (21% of arm)

•39 mo follow up

•Per protocol: bRFS (4) 81% with RT, 60% NFT (p<0.001)

•Intention to treat: bRFS (4) ~75% with RT, 60% NFT (SS)

Grade II rectal toxicity 3%

EORTC 22911: Bolla, 2005

•1,005 Patients underwent RP, node negative with + margins, + ECE, or SVI.

•Randomized to

–50Gy + 10Gy boost to bed

–Close observation (NFT)

•Mean f/u 5 years

•90% had PSA <0.2

•bPFS (5) 74% RT vs 53% NFT (p<0.001)

•Clinical Failure (5) 8.8% RT vs 19.0% NFT (p=0.009)

•No difference in OS or Distant Failures

•Grade 1-2 toxicity 45%NFT vs 60%RT (SS)

•Grade 3 toxicity ~4% for both (NS)