A very interesting letter to the editor in the NEJM about the Whelan Hypofractionation trial for breast cancer. In the manuscript, a subset analysis was performed suggesting that high grade cancers did worse with hypofractionation. In a letter, the investigators of the START A and B trial reanalyzed their data looking for a similar finding and found no difference, in fact the trend was for G3 cancers to do better with hypofx in their data set.
I have been shying away from hypofx in G3 patients until now, but this data will make me much more comfortable offering it to our patients.
Hypofractionated Radiotherapy for Breast Cancer: