Tuesday, November 16, 2010

HPV subtypes for cervical cancer worldwide

Lancet Oncology:

A large report of the prevalence of HPV subtypes causing cervical cancer is published, again confirming HPV 16, 18, 31, and 33 as the primary actors. Interestingly, it also highlights HPV 45, and the prevalence of HPV in cervical adenocarcinomas.


[Articles] Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study: "To our knowledge, this study is the largest assessment of HPV genotypes to date. HPV types 16, 18, 31, 33, 35, 45, 52, and 58 should be given priority when the cross-protective effects of current vaccines are assessed, and for formulation of recommendations for the use of second-generation polyvalent HPV vaccines. Our results also suggest that type-specific high-risk HPV-DNA-based screening tests and protocols should focus on HPV types 16, 18, and 45."

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