Tuesday, May 29, 2012

Capecitabine for Rectal Cancer

In Lancet Oncology:

A phase III trial comparing RT + capecitabine vs 5FU for rectal cancer - fortunately has confirmed what is already common practice in the US - capecitabine proved no worse (by their criteria).  All trends as well favored capcitabine for disease control.  Capcitabine proved more toxic however, in all but leukopenia.


[Articles] Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial: Capecitabine could replace fluorouracil in adjuvant or neoadjuvant chemoradiotherapy regimens for patients with locally advanced rectal cancer.

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